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Dr Sota Omoigui is an independent translational researcher, analyzing and applying patterns in basic science research to discover novel clinical applications.  He is the discoverer of the first solution in 7300 years to prevent and stop a sickle cell crisis in the golden half hour. Initial Hemoglobin S sickling is reversible with re-oxygenation within the first golden half hour. See https://www.youtube.com/watch?v=HM0b49txX4Q&t=41s

Dr Sota Omoigui is author of Sota Omoigui’s Anesthesia Drugs Handbook that has been translated into six languages. He is author of multiple articles on Pain and Inflammation. 

Since the dawn of time, 300,000 years ago, Mankind has tried to understand the origins of pain. From Athenian philosopher Plato (c. 428 to 347 B.C.) to the 1644 pain theory , by the French philosopher Renee Descartes to the 1965 gate control theory by Melzack and Wall. None of these theories have withstood the test of time. 

In his seminal book titled: The Biochemical Origin of Pain and published in 2002, Dr Sota Omoigui proposed his theoretical law that the origin of pain is due to inflammation and the inflammatory response.  His subsequent publication of his theory as a journal article in 2007 has been cited as of this date by 484 medical publications.  In his 2002 theory, he demonstrated a clear association between migraine and the release of inflammatory mediator calcitonin gene-related peptide (CGRP) and substance P (SP). In 2019, seventeen years later, the US FDA approved members of a new class of drugs specifically designed to treat migraine by targeting calcitonin gene-related peptide (CGRP). Those drugs have been the greatest advance in the treatment of migraine.

He has sought to revolutionize the treatment of pain from a structure based approach to an approach based on the treatment of inflammation and the inflammatory response. His academic articles have been cited more than 800 times. He has developed simple spinal injection procedures utilizing small and short 30 G needles based on the laws of physics and targeting multiple structures at once starting from  the much overlooked spinal muscles that do not show on CT Scans and MRIs. Such procedures replace invasive epidural procedures and can be performed by nurse practitioners and primary care physicians. 

His theory has been recently validated in 2023. As stated in the NIH, HEAL Initiative Fund Opportunity, the field of musculoskeletal pain has largely focused on the skeletal system (bones, joints, intervertebral discs) and central nervous system (brain and spinal cord) components.The perimuscular fascia is richly innervated with small-diameter fibers whose receptive fields increase in the presence of inflammation. Thus NIH has called for development of biomarkers of myofascial tissues for effective pain management.

In 2008 – 2011 – Sota Omoigui was Member, FDA Advisory Committee on Anesthetics and Life Support Devices. He is a recipient of the FDA Advisory Committee service award for service to the people of the United States of America

Sota Omoigui is a co-author of the 1978, Arise O Compatriots, All Nigerian National Anthem.

He holds 8 United States patents